China GMP Peptides Factory Direct Supply 99% High Quality Teriparatide Acetate Raw Powder CAS: 52232-67-4, Find details about China Teriparatide Acetate, Teriparatide Acetate Powder from China GMP Peptides Factory Direct Supply 99% High Quality Teriparatide Acetate Raw Powder CAS: 52232-67-4
Name | Teriparatide |
CAS | 12583-68-5 |
EINECS | N/A |
MF | C183H288N54O50S2 |
MW | 4108.71 |
Storage temp | -20°C |
Assay | 98% Min. |
Appearance | white crystalline powder |
Usage | an agonist at PTH1 and PTH2 receptors |
Teriparatide is a recombinant product representing the first 34 amino acids in human parathyroid hormone. Teriparatide increases bone formation, the bone remodeling rate, and osteoblast number and activity. Both bone mass and architecture are improved.
Teriparatide is FDA approved for postmenopausal women and men who are at high risk for fracture.
Candidates for therapy include patients with a history of osteoporotic fracture, multiple risk factors for fracture, very low bone density (e.g., T-score <-3.5), or those who have failed or are intolerant of previous bisphosphonate therapy.The drug reduces fracture risk in postmenopausal women, but no fracture data are available in men. Lumbar spine BMD increases are higher than with any other osteoporosis therapy. Although wrist BMD is decreased, wrist fractures are not increased.
TEST ITEMS | SPECIFICATIONS | RESULTS |
Appearance | White powder | Conforms |
Solubility | Soluble in water or 1% acetic acid | Conforms |
at a concentration of ≥1mg/ml to | ||
give a clear, colorless solution | ||
Specific Optical Rotation(c=0.5,1% HAc) | - -65.0~-75.0° | -70.2° |
Identity | Monoisotopic Mass: 4117.7±2.0 | 4116 |
Amino Acid Composition | ±20% | Conforms |
Related Substances | Total Impurities(%)≤ 5.0% | 0.80% |
Largest Single Impurity(%)≤ 2.0% | 0.30% | |
Peptide Purity (By HPLC) | ≥ 95.0% by area integration | 99.30% |
Acetate Content | ≤ 15% | 9.00% |
Water Content(Karl Fischer) | ≤ 8.0% | 2.50% |
Peptide Content(N determination) | ≥ 80.0% | 88.30% |
Assay(By Anhydrous, Acetic Acid-free ) | 95.0~105.0% | 99.00% |
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