China Factory Supply Original Powder Memantine 19982-08-2 Acs 19982-08-2 with Safe Delivery, Find details about China Memantine, CAS 19982-08-2 from Factory Supply Original Powder Memantine 19982-08-2 Acs 19982-08-2 with Safe Delivery
Product name | Memantine |
Cas number | 19982-08-2 |
Molecular formula | C12H22ClN |
Molecular weight | 215.76 |
Appearance | white powde |
Melting point | 153 |
Boiling point | 239.8 at 760 mmHg |
Relative density | 1.046 |
Memantine Benefits
Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European.
The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity.
Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs).
Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other.
Medical Use
Memantine is used to treat moderate-to-severe Alzheimer's disease, especially for people who are intolerant of or have a contraindication to AChE (acetylcholinesterase) inhibitors.One guideline recommends memantine or an AChE inhibitor be considered in people in the early-to-mid stage of dementia.
Memantine has been associated with a modest improvement; with small positive effects on cognition, mood, behavior, and the ability to perform daily activities in moderate-to-severe Alzheimer's disease. There does not appear to be any benefit in mild disease.
Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements" in a 2017 review. The UK National Institute of Clinical Excellence (NICE) issued guidance in 2018 recommending consideration of the combination of memantine with donepezil in those with moderate-to-severe dementia. Effects in autism are unclear. Recent scientific journal reports are showing guarded promise with severe obsessive compulsive disorder.
COA
Item | Requirements | Test Results |
appearance | White or almost white crystalline powder | White crystalline powder |
Identification | IR | Comply |
Related substance | 1-methyladamantane ≤0.3% 1,3,5 -trimethyladamantane ≤0.3% Unknow impuritiy ≤0.1% Total impurity ≤0.5% | 0.13% 0.14% <0.1% <0.4% |
Residue on ignition | ≤0.1% | 0.06% |
Heavy matal | ≤10ppm | <10ppm |
Loss on drying | ≤0.5% | 0.29% |
Assay | 98.5-101.0% | 99.13% |
Residual Solvents | Ethyl Acetat: ≤0.5% Ethanol: ≤0.5% | 0.08% 0.12% |
PH | 4.5-5.5 | 5.3 |
Microbial Limits | Max 5*102 aerobes and fungl per 1g E. Coli: Negative Salmonella: Negative
| Pass |
Size of distributed particles | Pass 100μ m | Conforms |
Conclusion | Meet the requirements |
Memantine HPLC & NMR Test Report-Yinherb Lab
Our Company
Wuhan Biocar Pharmaceutical Co., Ltd. is a high-tech innovative enterprise specializing in the R & D, production and sales of API and pharmaceutical intermediates (excluding drugs). Our company is based on the optical valley biological city, with the help of Wuhan University Scientific Research Laboratory, making full use of the park policy advantages, focusing on the research and development of biological medicine. Our company always adheres to the business philosophy of "market demand oriented; technology research and development as the core competitiveness; e-commerce as the platform", more accurate, better, faster and more reliable to provide biomedical products for pharmaceutical units, university scientific research institutions, hospital outpatient service, reagent units, distributors in the world.
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