Product descriptionVerapamil hydrochloride is an α-adrenergic receptor (α-AR) antagonist and calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein). Verapamil is a substrate of CYP3A4 and CYP2C6.
Application
Verapamil hydrochloride is a medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia.It may also be used for the prevention of migraines and cluster headaches.
Package25kg/drum
SpecificationMelting point: 140-144º C
Description: White crystalline powder
Content(HPLC): ≥ 99.0%
Loss On Drying: ≤ 5%
Sulphated Ash: ≤ 5%
Heavy Metal: ≤ 10PPM
Total microbacterial count: NMT 1000cfu/g
Salmonella: NMT100cfu/g
Total Yeast & Mold: Negative
E. Coli.: Negative