Sotorasib (AMG 510) is being developed by Amgen. Phase 1 clinical trials were completed in late 2020. In December 2019, it was approved to begin Phase 2 clinical trials.

Because the G12C KRAS mutation is relatively common in some cancer types, 14% of non-small-cell lung cancer adenocarcinoma patients and 5% of colorectal cancer patients, and sotorasib is the first drug candidate to target this mutation, there have been high expectations for the drug.The Food and Drug Administration has granted a fast track designation to sotorasib for the treatment of metastatic non-small-cell lung carcinoma with the G12C KRAS mutation.

Function
AMG-510 is a KRAS G12C inhibitor. Because it interrupts protein signaling, it causes KRAS G12C tumor regression.

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Quality is the life of our factory, first, each raw materials, come to our factory, we will test it firstly, if qualified, we will process the manufacturing with this raw materials, if not, we will return it to our supplier, and after each manufacturing step, we will test it, and then all the manufacturing process finished, we will do the final test before the commodities left our factory.

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