China Anti-Tumor Amg 510 Active Powder Amg510 Safe Passed The Customs, Find details about China Amg510, CAS 2252403-56-6 from Anti-Tumor Amg 510 Active Powder Amg510 Safe Passed The Customs
Product Name | AMG 510 / Sotorasib |
CAS No. | 2252403-56-6 |
Appearance | White Powder |
Molecular Formula | C30H30F2N6O3 |
Molecular Weight | 560.59 |
Density | 1.36±0.1 g/cm3(Predicted) |
Boiling Point | 730.5±70.0 °C(Predicted) |
Shelf Life | 2 Years |
MOQ | 10 Gram |
Sotorasib (AMG 510) is being developed by Amgen. Phase 1 clinical trials were completed in late 2020. In December 2019, it was approved to begin Phase 2 clinical trials.
Because the G12C KRAS mutation is relatively common in some cancer types, 14% of non-small-cell lung cancer adenocarcinoma patients and 5% of colorectal cancer patients, and sotorasib is the first drug candidate to target this mutation, there have been high expectations for the drug.The Food and Drug Administration has granted a fast track designation to sotorasib for the treatment of metastatic non-small-cell lung carcinoma with the G12C KRAS mutation.
Function
AMG-510 is a KRAS G12C inhibitor. Because it interrupts protein signaling, it causes KRAS G12C tumor regression.