China Nicotinamide Adenine Dinucleotide Supplier CAS 53-84-9 Nad Powder Manufacturer, Find details about China Nad, Nad Price from China Nicotinamide Adenine Dinucleotide Supplier CAS 53-84-9 Nad Powder Manufacturer
Introduction
Name | High quality NAD beta-Nicotinamide adenine Dinucleotide Cas 53-84-9 |
Appearence | white powder |
Molecular Formula | C21H27N7O14P2 |
Molecular Weight | 663.425 |
CAS No | 53-84-9 |
Standard | Medicine grade, Cosmetic grade |
Assay | 90%-99% |
Quality | Best quality for Diphosphopyridine nucleotide |
Solubility | Water soluble |
EINECS No | 200-184-4 |
Nicotinamide adenine dinucleotide ( NAD ) is a coenzyme found in all living cells. The compound is a dinucleotide, because it consists of two nucleotides joined through theirphosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms: an oxidized and reduced form abbreviated as NAD+ and NADH respectively.
Main Function
1. Nutritional peptides enhance the assimilation of mineral elements.
2. Nucleotides develop nthe immunity and enable animals to produce more IgG and IgM.
3. Nucleotides promote intestinal and bring regeneration of benefical bacteria.
4. Nucleotides accelerate the liver recovery from damages.
5. Mannan oligosaccharides absorb pathogenic bacteria and take them out of bodies.
6. Beta-glucan activate macrophages to improve animal immunity.
7. I+G improve feed palatability and increase the intake
Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as acoenzyme inredox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of thesecond messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. In addition to these metabolic functions, NAD+ emerges as an adenine nucleotide that can be released from cells spontaneously and by regulated mechanisms, and can therefore have important extracellularroles.
The enzymes that make and use NAD+ and NADH are important in both pharmacology and the research into future treatments for disease. Drug design and drug development exploits NAD+ in three ways: as a direct target of drugs, by designing enzyme inhibitors or activators based on its structure that change the activity of NAD-dependent enzymes, and by trying to inhibit NAD+biosynthesis.
The coenzyme NAD+ is not itself currently used as a treatment for any disease. However, it is being studied for its potential use in the therapy of neurodegenerative diseases such asAlzheimer's andParkinson disease. Evidence on the benefit of NAD+ in neurodegeneration is mixed; some studies inmice have produced promising results whereas a placebo-controlled clinical trial in humans failed to show any effect.
NAD+ is also a direct target of the drug isoniazid, which is used in the treatment oftuberculosis, an infection caused by Mycobacterium tuberculosis. Isoniazid is a prodrug and once it has entered the bacteria, it is activated by a peroxidase enzyme, which oxidizes the compound into a free radicalform. This radical then reacts with NADH, to produce adducts that are very potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolate reductase. In one experiment, mice given NAD for one week had improved nuclear-mitochrondrial communication.
Application
Nicotinamide Adenine Dinucleotide is a water-soluble vitamin, The product is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin.
Nicotinamide Adenine Dinucleotide is easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II, plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.
In addition, Nicotinamide Adenine Dinucleotide has prevention and treatment of heart block, sinus node function and anti fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atrioventricular block caused by verapamil.
COA of NAD
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1.
why choose our comp
any
1. quality
our products meet msds safe standard and we have iso and other certificate so yan can get high quality products from our company.
2. price
we are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.
3.packing
we can do according to the customers' request.
4.transport
ems,dhl, tnt, ups ,fedex, by air, by sea
dhl express, fedex and ems for quantity less than 50kg, usually called as ddu service;
sea shipping for quantity over 500kg; and air shipping is available for 50kg above;
for high value products, please select air shipping and dhl express for safe;
5.service
we offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.
we will try our best to satisfied you.
1. tailor-made for every customers.
2. third-party test for the products you demand.
3. test your counter-samples and produce them for you.
4. best discount for old customers.
Thanks for your considering of Hebei Guanlang Biotechnology Co., Ltd.(Crovell). Crovell is a fast growing intermediates company,Which located in Shijiazhuang,Hebei Province.
Crovell is specialized in pharmaceutical intermediates, veterinary drug intermediates and dyes intermediates,such as phenylacetamide, dimethylamine hcl, benzyl chloride etc., Crovell also supply various industrial chemicals for customers, such as citric acid,potassium chloride etc.
After ten years development,Crovell has become a Diversified development company,not only involves in chemicals, but also real estate ,clothes ,agricultural products and so on.
So far, Crovell has business in more than 35 countries,most big customers come from europe and America, because among the suppliers in china,Crovell can always make the product quality best, some of the products from Crovell can reach the purity of 99.9+, such as 2-phenylacetamide. This is the important reason for customers who choosing Crovell.
In future, Crovell must become to a more important trade bridge for china and foreign countries especially in pharmaceutical industries.
Packaging Details:
25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside
Delivery Detail: within 10 days when get the payment.
Shipping :
We have Professional shipping agent, based on customers ' demand for transport
By express :FEDEX,DHL,EMS ,UPS,TNT ect.
By SEA and By AIR