China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632 -25-9

China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632-25-9, Find details about China Pramipexole HCl, Pramipexole Hydrochloride Powder from China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632-25-9

Appearance
White Powder
CAS
104632-25-9
Mf
C10h19cl2n3s
MW
206.24
Grade
Medicine Grade
Trademark
WHOK
Transport Package
Discreet and Disguised
Specification
As your request
Origin
China
HS Code
3001200020
Appearance
White Powder
CAS
104632-25-9
Mf
C10h19cl2n3s
MW
206.24
Grade
Medicine Grade
Trademark
WHOK
Transport Package
Discreet and Disguised
Specification
As your request
Origin
China
HS Code
3001200020

Product Description

Product Name

 

Pramipexole Hydrochloride

 

 Other Name

 

Pramipexole HCl 

 

CAS NO:

 

104632-25-9

 

Molecular Formular

 

C10H19Cl2N3S

 

EINECS NO

 

226-500-0

 

MW

 

 206.24

 

Appearance

 

white powder

 

Place of origin

 

China

Product Introduction

 

Pramipexole hydrochloride is a kind of drugs for treatment of Parkinson syndrome. It belongs to selective non-ergot dopamine receptor agonist. It was first successfully developed by Boehringer Ingelheim Company (Germany). It is a prescription drugs of dopamine receptor agonist applied in the largest amount of the world. In May, 1997, it had been approved for the first time by FDA for the treatment of idiopathic Parkinson's disease. It can reduce the symptoms and sign, and can either be used alone or in combination with levodopa. The trade name of the good marketed in the United States is Mirapex, which is the first drugs approved the FDA during the past six years for treatment of Parkinson syndrome. In 2007, it has entered into market in China with the commodity name being sifrol for the treatment of the signs and symptoms of idiopathic Parkinson's disease, being used either alone (without levodopa) or in combination with levodopa.

Product Usage

1. It can relieve the motor symptoms of Parkinson's disease: Parkinson's disease is cause due to the dopamine deficiency resulting from the loss of dopaminergic neuron, leading to patients get a series of symptoms such as tremors, muscle rigidity, slow movement and so on. Pramipexole hydrochloride can highly selective act on dopaminergic D2 and D3 receptors, thereby, stimulating the release of dopamine in the brain and alleviating the motor symptoms. Shannon et al have shown that early Parkinson's disease patients who has received pramipexole monotherapy can effectively have their motor symptoms be within control and can maintain daily living. When being used in combination with levodopa, pramipexole can effectively improve both the ADL score and the motor symptoms score of patients with advanced Parkinson's disease, and thus making the life of the patients with advanced Parkinson's disease more active.

2. it can significantly alleviate the depressive symptoms associated with Parkinson's disease: the pramipexole hydrochloride is a kind of agonists of dopamine D2, D3 receptor. The dopamine D3 receptor system may be associated with the patient's mood and behavior. Since pramipexole can selectively stimulate the D3 receptor with a higher agonist efficacy than D2 receptors, it can significantly relieve symptoms of depression. In study of Barone (Italy) et al, when patients with Parkinson's disease had been treated with pramipexole or sertraline, the proportion of patients with alleviated depression symptoms in pramipexole group was significantly higher than that of the sertraline group. Researchers believe that dopamine agonists (pramipexole) can substitute antidepressants to treat the depression of patients with Parkinson disease.

3.Pramipexole has protective effect on damaged neurons as well as excellent control of the jitter symptom. It has the least side effects in the field of Parkinson syndrome. Moreover, it has a large scope for adjusting drug in later phase, which is good for the following treatment. It can prevent the nerve damage caused by long-term use of levodopa, delaying the time needed for levodopa treatment as well as reducing the dose of levodopa.

COA

ItemsSpecificationResults
CharacterOff-white to white crystalline powderOff-white crystalline powder
Solubility
 
Soluble in Water and Methanol, slightly soluble in Ethanol (96%), Almost insolubleComplies
IdentificationSpecific Rotation -67-69.5° (on anhydrate basis)-67.4
(2) IR:Meets the requirement.Complies
(3) Optical purity Test
(4) Chloride Reaction
ClarityClear,not deeper than Y6.
PH2.8-3.42.9
Related SubstancesImpurity A≤0.15%0.03%
Impurity B≤0.15%Not detected
Impurity C ≤0.15%0.04%
Unknown single impurity ≤0.15%0.07%
0.1% Total Impurity≤0.5%0.18%
Impurity DImpurity D≤0. 5%0.05%
Water4.5%-6.5%5.7%
Heavy metals≤10ppmcomplies
Sulfate Ash≤0.1%0.04%
Assay99.0%~101.0%99.4%

Tags

Pramipexole Hydrochloride Powder,Pramipexole Dihydrochloride Powder,Pramipexole HCL Powder,Pramipexole Hydrochloride Powder, Pramipexole Dihydrochloride Monohydrate Manufacturer

Our Market

China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632-25-9

Shipment Way

China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632-25-9

Our Advantages

China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632-25-9China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632-25-9China GMP Factory Direct Supply 99% Purity Pramipexole HCl / Pramipexole Hydrochloride Powder CAS: 104632-25-9