Pharmaceutical Intermediate R Emdesivir Intermediates /GS-441524 CAS: 1191237-69-0
China Pharmaceutical Intermediate R Emdesivir Intermediates /GS-441524 CAS: 1191237-69-0, Find details about China Fipv, CAS 1191237-69-0 from Pharmaceutical Intermediate R Emdesivir Intermediates /GS-441524 CAS: 1191237-69-0
Basic Info.
Model NO.
GS 441524
Apearance
White Powder
CAS
1191237-69-0
Mf
C12h13n5o4
MW
291.26
Einecs No.
200-001-8
Density
1.74-1.94 g/cm3
Storage
Cool Dry Place
Shelf Life
2 Years
Deliver Time
7-10days
Trademark
Biocar
Transport Package
Bag or Drum
Specification
1kg/Bag; 25kg/Drum
Origin
Guangzhou, Guangdong, China
HS Code
2937900090
Model NO.
GS 441524
Apearance
White Powder
CAS
1191237-69-0
Mf
C12h13n5o4
MW
291.26
Einecs No.
200-001-8
Density
1.74-1.94 g/cm3
Storage
Cool Dry Place
Shelf Life
2 Years
Deliver Time
7-10days
Trademark
Biocar
Transport Package
Bag or Drum
Specification
1kg/Bag; 25kg/Drum
Origin
Guangzhou, Guangdong, China
HS Code
2937900090
Product Desciption
Pharmaceutical Intermediate R Emdesivir Intermediates /GS-441524 CAS: 1191237-69-0
Basic Information
Product Name :GS-441524
Trade Name:GS441
CAS No.:1191237-69-0
Molecular Formula: C12H13N5O4
Molecular Weight:291.26g/mol
Purity : 98% HPLC
Appearance: Clear Liquid
Typical use:Cat FIP Treatments
Shelf Life :2 years
Payment Terms:T/T, Western Union, Money Gram
Storage:Refrigeration keep dry and away from light.
Description
Wet FIP Cat
Questions and Answers Related to GS-441
Q: What is GS-441?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field .
It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please checking with Julia for the details!
Q: How long is the treatment?
A: Recommended treatment based on Niche Petcare is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat's symptoms should be assessed to see if additional treatment is needed.
Q: What is the correct dose of GS to give my kitty?
A: Dosing is based on the weight of the cat.
If you love math, the formula to calculate is:
5mg*(GS) x weight(kg) / GS concentration per 1mL**=dose per 24hr
*Neurological and Ocular FIP cats require 8mg/kg MINIMUM.
Can go as high as 10mg/kg for extreme ocular or neurological cases.
*GS concentration per 1ml = total GS in bottle (mg) / total solution volume (mL)
Q: What exactly are "neuro" or "ocular" cases?
A: "Neuro" cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected
Q: What are the details with the oral treatment?
A: Oral Pills:
Dosage is 1 pill equals 10mg .
Neuro dosage: Please contact us for dosage. We would have to calculate and itdepends on all different cases.
Price is $8 per pill.
Q: What size syringes and needles do I need?
A: Depending on what your cat's dose is, you can used either a 1 mL or a 3 mL syringe. Use a 20 gauge needle to draw up the GS into the syringe and then it's best to CHANGE the needle to a fresh one of the same size OR SLIGHTLY SMALLER (21 or 22 gauge) to inject. The GS liquid is somewhat thick and a larger needle allows it to be drawn up and injected faster. The LENGTH of needle can be anywhere from 1/2" to 1 1/2" in length. It's a bit of a personal preference. Some usethe longer needles to try and avoid any GS leaking out, some are more comfortable injecting with a shorter needle. You DEFINITELY want Luer-lock needles so they can be secured to the syringes and not pop off.
A NOTE ON NEEDLE GAUGE SIZES: The number used to describe the circumference or "width" of the needle opening gets larger as the size of the opening gets smaller. For example, an 18 gauge needle has a larger opening than a 21 gauge needle.
Q: How do I give the GS injections?
A: The injections are given sub-cutaneously or "sub-cu" which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It's best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet.
Q: What are the side effects of GS?
A: The only known side effects of GS are pain during injections and the possibility of skin lesions forming at the injection sites.
Q: My kitty is on GS and now has diarrhea. What should I do?
A: We recommend giving B-12, bland food and a probiotic. Pumpkin puree is also okay to give. Fortiflora or Proviable are two probiotics. If the cat seems to be getting dehydrated, giving sub-cutaneous fluids is okay
Q: Should I continue to use flea/tick treatment for my FIP kitty during treatment?
A: No. Do not use Revolution, Frontline or other chemical flea/tick treatments while on FIP treatment. The biggest part of treating for fleas is the environment. Vacuum daily (floors, closets, bedding, anything the cats come in contact with) and wash all bedding. You can flea comb your cat daily to remove fleas. You can make a mixture of water and apple cider vinegar (2:1) to apply on a cloth and wipe onto your cat daily so the fleas don't want to be on her. Revolution is one of the moresafe options, but I would hesitate to combine it with GS for fear of affecting the GS being able to have full effect.
Q: How long after completing FIP treatment should I wait to spay/neuter my cat?
A: 3 months.
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Shipping And Packaging
Basic Information
Product Name :GS-441524
Trade Name:GS441
CAS No.:1191237-69-0
Molecular Formula: C12H13N5O4
Molecular Weight:291.26g/mol
Purity : 98% HPLC
Appearance: Clear Liquid
Typical use:Cat FIP Treatments
Shelf Life :2 years
Payment Terms:T/T, Western Union, Money Gram
Storage:Refrigeration keep dry and away from light.
Description
Wet FIP Cat
- Water in the chest and abdomen
- Poor appetite
- Persistent fever
- depression
- dyspnea
- lymphadenopathy
- Jaundice diarrhea
- Failure of dehydration
- Iris lesions
- After flooding weak
| Name | GS-441524 |
| Appearance | Transparent liquid |
| GS Standard | 99.9%min |
| Size | 3 ~ 5.5 ml Vial |
| Content | 15 or 22.5mg/ml min |
| Application | For CAT FIP R&D Use ONLY |
| Wet FIP | 8 mg/kg |
| Dry FIP | 5mg/kg |
| Ocular or Neuro FIP | 8 mg/kg |
| Increased ocular/neuro | 9 mg/kg |
| Max ocular/neuro | 10 mg/kg |
| Content | 5mg /2mL (15mgGS-441524+30mg synergist) purity> 98% |
| Instructions | 1. It is recommended that conventional cases 0.2-0.5ml per kilogram body weight, subcutaneous injection, once a day. 2. It is recommended to inject continuously for at least 4 weeks. Based on the results of the clinical examination, the veterinarian determines the time to stop the drug. |
| Precautions | 1. Pain at the injection site, especially within 1 minute of injection, lasting for half an hour; 2. Malabsorption may occur at the injection site, causing subcutaneous swelling and ulceration (rare); 3. It is recommended to avoid stress after clinical treatment is resumed and drug withdrawal is stopped, such as changing the environment, sterilization, and raising new cats for at least 6 months. 4. This medicine is only used for scientific research experiments. |
| Size | 13.5*10.5*19.5cm |
Questions and Answers Related to GS-441
Q: What is GS-441?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field .
It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please checking with Julia for the details!
Q: How long is the treatment?
A: Recommended treatment based on Niche Petcare is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat's symptoms should be assessed to see if additional treatment is needed.
Q: What is the correct dose of GS to give my kitty?
A: Dosing is based on the weight of the cat.
If you love math, the formula to calculate is:
5mg*(GS) x weight(kg) / GS concentration per 1mL**=dose per 24hr
*Neurological and Ocular FIP cats require 8mg/kg MINIMUM.
Can go as high as 10mg/kg for extreme ocular or neurological cases.
*GS concentration per 1ml = total GS in bottle (mg) / total solution volume (mL)
Q: What exactly are "neuro" or "ocular" cases?
A: "Neuro" cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected
Q: What are the details with the oral treatment?
A: Oral Pills:
Dosage is 1 pill equals 10mg .
Neuro dosage: Please contact us for dosage. We would have to calculate and itdepends on all different cases.
Price is $8 per pill.
Q: What size syringes and needles do I need?
A: Depending on what your cat's dose is, you can used either a 1 mL or a 3 mL syringe. Use a 20 gauge needle to draw up the GS into the syringe and then it's best to CHANGE the needle to a fresh one of the same size OR SLIGHTLY SMALLER (21 or 22 gauge) to inject. The GS liquid is somewhat thick and a larger needle allows it to be drawn up and injected faster. The LENGTH of needle can be anywhere from 1/2" to 1 1/2" in length. It's a bit of a personal preference. Some usethe longer needles to try and avoid any GS leaking out, some are more comfortable injecting with a shorter needle. You DEFINITELY want Luer-lock needles so they can be secured to the syringes and not pop off.
A NOTE ON NEEDLE GAUGE SIZES: The number used to describe the circumference or "width" of the needle opening gets larger as the size of the opening gets smaller. For example, an 18 gauge needle has a larger opening than a 21 gauge needle.
Q: How do I give the GS injections?
A: The injections are given sub-cutaneously or "sub-cu" which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It's best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet.
Q: What are the side effects of GS?
A: The only known side effects of GS are pain during injections and the possibility of skin lesions forming at the injection sites.
Q: My kitty is on GS and now has diarrhea. What should I do?
A: We recommend giving B-12, bland food and a probiotic. Pumpkin puree is also okay to give. Fortiflora or Proviable are two probiotics. If the cat seems to be getting dehydrated, giving sub-cutaneous fluids is okay
Q: Should I continue to use flea/tick treatment for my FIP kitty during treatment?
A: No. Do not use Revolution, Frontline or other chemical flea/tick treatments while on FIP treatment. The biggest part of treating for fleas is the environment. Vacuum daily (floors, closets, bedding, anything the cats come in contact with) and wash all bedding. You can flea comb your cat daily to remove fleas. You can make a mixture of water and apple cider vinegar (2:1) to apply on a cloth and wipe onto your cat daily so the fleas don't want to be on her. Revolution is one of the moresafe options, but I would hesitate to combine it with GS for fear of affecting the GS being able to have full effect.
Q: How long after completing FIP treatment should I wait to spay/neuter my cat?
A: 3 months.
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Shipping And Packaging
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8.Raw materials from Chinese origin.
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A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
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A:For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantity, we always support with better price.
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First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
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