China Manufacturer Supply Local Anesthetic Powder Benzocaine for Anti-Paining CAS 94-09-7 USP Bp Grade Benzocaine CAS94-09-7 100 % Pass Safe Delivery to Door
China Manufacturer Supply Local Anesthetic Powder Benzocaine for Anti-Paining CAS 94-09-7 USP Bp Grade Benzocaine CAS94-09-7 100% Pass Safe Delivery to Door, Find details about China 94-09-7, Benzocaine from China Manufacturer Supply Local Anesthetic Powder Benzocaine for Anti-Paining CAS 94-09-7 USP Bp Grade Benzocaine CAS94-09-7 100% Pass Safe Delivery to Door
Benzocaine
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Use of BenzocaineBenzocaine shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV. |
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.
Benzocaine Biological Activity
| Description | Benzocaine shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV. |
|---|---|
| Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease |
| Target | IC50: 0.8 mM (Na+ channel)[1]. |
| In Vitro | Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type[1]. The inhibition of Ca2+ uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity[2]. |
| In Vivo | A common Benzocaine-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing[3]. |
| References | [1]. Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302. [2]. Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70. [3]. Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 310.7±15.0 °C at 760 mmHg |
| Melting Point | 88-90 °C |
| Molecular Formula | C9H11NO2 |
| Molecular Weight | 165.189 |
| Flash Point | 164.2±17.9 °C |
| Exact Mass | 165.078979 |
| PSA | 52.32000 |
| LogP | 1.95 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.555 |
| Storage condition | 0-6°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
1. Stored in a clean, cool and dry area; keep away from strong, direct light.
2. Shelf Life is 2 years when properly stored.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (36*36*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. In stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement
Shipping:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
Hot sell products:
| CHEMICAL NAME | CAS No. | STATE | PRICE | FREE SAMPLE |
| Benzocaine | 94-09-7 | IN STOCK | Negotiable | Available |
| Benzocaine HCI | 23239-88-5 | IN STOCK | Negotiable | Available |
| Lidocaine | 137-58-6 | IN STOCK | Negotiable | Available |
| Lidocaine hydrochloride | 73-78-9 | IN STOCK | Negotiable | Available |
| Tetracaine | 94-24-6 | IN STOCK | Negotiable | Available |
| Boric acid | 11113-50-1 | IN STOCK | Negotiable | Available |
| Levamisole (hydrochloride) | 16595-80-5 | IN STOCK | Negotiable | Available |
| Procaine (HCI) | 51-05-8 | IN STOCK | Negotiable | Available |
| Procaine | 59-46-1 | IN STOCK | Negotiable | Available |
Payment term:
We accept various payment terms, the main methods are : T/T, L/C, Western Union, credit card, Bitcoin, USDT etc.
Shipping term:
WHY CHOOSE US
MU LEI (Wuhan) is committed to helping clients reach their goals, to providing high quality products and efficient shipments.
Our strong sense of responsibility with client projects means that we are constantly striving to provide solutions, even for issues they aren't yet aware of.
This sense of responsibility also means we value and promote seamless interaction with clients, and ensure the best value is obtained from their research budget.
Our staff bring professional knowledge to clients, as well as efficient responding to the clients, have built long-term cooperated relationships.
QWhat's your advantage?
AThe series of natural extracted product are all self-developed, produced and tested. Mature production technology, strict quality management system and cost control system, ensure the product stability and competitive price.
QHow to deal with quality complaints or the goods get loss?
AFirstly, every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA (or depends on customers' request).
If it is our product quality issue or due to the force majeures, we will send you another shipment for free.
QIs there any discount?
AThe price is negotiable. The more bigger quantity you order, the more competitive price you would get.
QHow do you manage the delivery?
AGoods will be shipped within 24 hours (Chinese public holiday are excluded), usually shipping by DHL, Fedex, EMS, TNT, HKETK. We will ship with the special safe channel to ensure you getting goods on time.QHow to place an order?
AInquiry + payment + shipping.
Firstly, please send inquiry infor to us, including quantity, your target price, shipping method, packing request, destination etc. We will reply you the quotation and lead time within 1-8 hours (different time zone).
Second, pay for the order, we accept various payment terms, the main methods are: T/T, L/C, Western Union, credit card, BitCoin, USDT, Money Gram.
After received the payment, we will ship out products immediately and share tracking number with you.
And for sure, we keep tracking the shippment, and we provide after-service.
QCan I get some samples?
AWarmly welcome, we can provide samples for free, but the shipping cost will be covered by customers.
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