Factory Supply 99% Original Powder Mifepristone CAS 84371-65-3 with Safe Delivery and Cheap PriceProduct Details
describeMifepristone, also known as anti-progesterone, cibrix, cibrix, cytopenol, simiane and minastrone, is a new type of anti-fertility drug that acts on the receptor level and has no activity of progesterone, androgen and estrogen, which was first developed by Roussel-UolSF in France in the early 1980s. It was first marketed in France in 1988. Main role in endometrial progesterone receptor, can compete with progesterone receptor and the glucocorticoid receptor, has high affinity, endometrial progesterone receptor affinity for five times stronger than progesterone, under the effective dose of cortisol Chemicalbook had no obvious effect, can produce a strong resistance to progesterone effect, make the pregnancy decidua and villi tissue degeneration, Endogenous prostaglandin release, leading to uterine contraction, and can reduce the production of human chorionic gonadotropin, luteinysis, so that the embryo abortion. Because this drug can not cause enough uterine activity, the incomplete abortion rate is higher when used only in early pregnancy, but it can increase the sensitivity of uterus to prostaglandin. Therefore, adding small dose of prostaglandin can not only reduce the adverse reactions of prostaglandin, but also significantly increase the complete abortion rate. In addition, mifepristone also has the effect of softening and dilating the cervix
Function
Mifepristone has a strong anti-progesterone activity. Animal experiments show that the binding force of mifepristone to progesterone receptor is 3-5 times higher than that of progesterone. Mifepristone mainly acts on the endometrium and competes with endogenous progesterone to bind receptors at the molecular level to produce a strong anti-progesterone effect and produce the following physiological activities:
- Competitive occupation of progesterone receptors in the decidua causes the withdrawal of progesterone, denaturation and necrosis of decidua tissues, secondary damage and dissection of villi, decrease of HCG level and dissolution of corpus luteum of Chemicalbook. The mechanism is that mifepristone directly acts on the syncytic cytotrophoblast, resulting in a dosedependent decrease in the production rate of HCG, HPL and P.
- promote endogenous prostaglandin release, leading to uterine contraction.
- At the same time, it also acts on the anterior hypophysis of the hypothalamus, prompting the decline of FSH and LH and luteinysis, thus making pregnancy failure dependent on luteinization maintenance and leading to abortion.
- Acting on the cervix to soften and expand, which is conducive to the discharge of the embryo sac and decidua.
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We'd like to offer the samples for the quality evaluation,the shipping cost is borne by customers.
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Powder: PE bag, glass bottle or PTFE bottle for inner packing
Liquid: glass bottle or PTFE bottle for inner packing
Bulk order: Fiber drum or steel drum.
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FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you.The sample within 5 days, and bulk order within 7 days.
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A: Parcel will be shipped out in 3 working days after payment. Usually we use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on.
6.Is there a discount?
A: Yes, for larger quantity, we always support with better price.
7.What's your MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
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